Novak Djokovic is the only Big 3 champion playing the US Open—and stands as a major favorite to win his fourth Flushing Meadows title.

Oddschecker lists Djokovic as a 5 to 6 favorite to collect his second Grand Slam title of the year and 18th major crown overall.

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Daniil Medvedev, who pushed Rafael Nadal to five sets in the 2019 US Open final, is the second favorite at 13 to 2 followed by Stefanos Tsitsipas (8/1), three-time major finalist Dominic Thiem (10/1) and Milos Raonic and Alexander Zverev, both listed at 22/1.

Bettors back Djokovic as well, though not quite as strongly as bookmakers.

"Novak Djokovic is still the most popular choice, but doesn’t have quite as much of a stranglehold on the market as Serena Williams does on the women's side," Oddschecker's Pete Watt told Tennis Now. "Novak accounts for 36.46% of wagers at time of writing, putting him well clear of Daniil Medvedev with 17.71%.

"Last year’s French Open finalist Dominic Thiem comes in next best-backed with 10.42%, while Andy Murray at +4000 is fourth most popular with 6.25% – great to see him back!"

Photo credit: US Open Facebook