Stefanos Tsitsipas saved all eight break points he faced sweeping Casper Ruud 6-1, 6-4 to win his third Monte-Carlo Masters crown in the last four years.
The Americans remained undefeated in BJK Cup qualifier ties under the new format.
Winless in 11 prior sets vs. Novak Djokovic, Casper Ruud stunned the top seed, 6-4, 1-6, 6-4 charging into his maiden Monte-Carlo final.
The Greek will return to the Top 10 in next week's rankings.
Go inside the numbers of quarterfinal day in Monte-Carlo and look ahead to Saturday's semis.
Novak Djokovic broke serve five times in a 7-5, 6-4 win over Alex de Minaur to reach his first Monte-Carlo semifinal since 2015.
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