The World No.4 was dominant in every phase of the game in Dallas on Wednesday night.
Daniil Medvedev saved a match point in the second set, but fell in three to Italian qualifier Mattia Bellucci.
Defending champion Elena Rybakina beat qualifier Katie Volynets 2-6, 6-4, 6-4 to score her fifth straight win at the Mubadala Abu Dhabi Open.
Defending champion Tommy Paul held off Jenson Brooksby 6-7(6), 6-3, 6-4 for his fifth straighht Dallas Open victory.
The two-time major champion had her Hall of Fame career disrupted by a doping ban.
It wasn't a cakewalk but the Spaniard got the job done.
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