There are 40 players making their US Open debut in the men’s and women’s singles draws, 20 on the women’s side and 21 on the men’s. There are a total of 18 Grand Slam debuts - eight on the women's side and ten on the men's.
There are also a total of 42 players searching for their first win at a Grand Slam. Here they all are, in lists…
WTA debuts at US Open (7 wins 13 losses)
1. Usue Maitaine ARCONADA, USA, 21 (Loss to Juvan 6-4 7-6(2))
2. Haley BAPTISTE, USA, 18 (Loss to Mladenovic 7-5, 6-2)
3. Ysaline BONAVENTURE, BELGIUM, 26 (d. Zhang 4-6 6-3 6-2)
4. Leylah FERNANDEZ, CANADA, 17 (d. Zvonareva 6-4 7-5)
5. Varvara GRACHEVA,RUSSIA, 20 (d. Badosa 6-4 7-5, R1)
6. Maddison INGLIS, AUSTRALIA, 22 (Loss to Linette, 6-4 4-6 6-4)
7. Kaja JUVAN, SLOVENIA, 19 (d. Arconada 6-4 7-6(2))
8. Katarzyna KAWA, POLAND, 27 (Loss to Jabeur, 6-2 7-6(6))
9. Irina KHROMACHEVA, RUSSIA, 25 (Loss to Rogers 6-3 6-2)
10. Tamara KORPATSCH, GERMANY, 25 (Loss to Bellis, 6-7(13), 6-3 6-2)
11. Marta KOSTYUK, UKRAINE, 18 (d. Kasatkina 6-1 6-2)
12. Ann LI, USA, 20 (d. Rus 6-4 2-6 6-1)
13. Greet MINNEN, BELGIUM, 23 (Lost to Vondrousova, 6-1 6-4, R1)
14. Robin MONTGOMERY, USA, 15 (Loss to Putintseva 6-1 6-3)
15. Jasmine PAOLINI, ITALY, 24 (Loss to Garcia 6-3 6-2)
16. Luidmila SAMSONOVA, RUSSIA, 21 (Loss to Pironkova 6-2 6-3)
17. Katrina SCOTT, USA, 16 (d. Vikhlyantseva 7-6(3) 6-2)
18. Nina STOJANOVIC, SERBIA, 24 (Loss to Kalinskaya 6-4 6-3)
19. Viktoriya TOMOVA, BULGARIA, 25 (Loss to Anisimova 7-5 7-5)
20. Katarina ZAVATSKA, UKRAINE, 20 (Loss to Rybakina 6-3 6-0)
Men’s Singles, US Open Debuts (8 wins, 12 losses)
1. Attila Balazs (HUN), 31 (Loss to Kukushkin 6-4 7-5 6-4)
2. Ulises Blanch (USA), 22 (Loss to Garin 4-6 5-7 6-4 6-4 6-2)
3. Salvatore Caruso (ITA), 27 (d. Duckworth 4-6 7-5 7-5 6-2)
4. Federico Coria (ARG), 28 (d. Jung 2-6 4-6 6-4 6-1 2-0 RET)
5. Maxime Cressy (USA), 23 (d. Kovalik 6-1 2-6 6-4 6-4)
6. Alejandro Davidovich Fokina (ESP), 21 (d. Novak 3-6 6-4 6-3 1-6 6-0)
7. Jason Jung (TPE), 31 (Loss to Coria 2-6 4-6 6-4 6-1 2-0 RET)
8. Sebastian Korda (USA), 20 (Loss to Shapovalov 6-4 4-6 6-3 6-2)
9. Gianluca Mager (ITA), 25 (Loss to Kecmanovic 6-4 6-4 6-7(6) 3-6 6-2)
10. Pedro Martinez (ESP), 23 (Loss to Struff 6-0, 7-5 6-4)
11. Brandon Nakashima (USA), 19 (d. Lorenzi 6-3 6-2 7-6(3))
12. Christopher O’Connell (AUS), 26 (d. Djere 4-6 6-4 7-6(2) 6-4)
13. Marc Polmans (AUS), 23 (Loss to Giron 6-4 6-7(5) 3-6 6-4 6-2)
14. Emil Ruusuvuori (FIN), 21 (d. Bedene 6-3 3-6 6-1 4-6 6-1)
15. Mohamed Safwat (EGY), 29 (Loss to Simon 6-1 6-4 6-4)
16. Thiago Seyboth Wild (BRA), 20 (Loss to Evans 6-1 6-2 7-6(5))
17. Pedro Sousa (POR), 32 (Loss to Krueger 3-6 6-2 7-5 6-3)
18. Yasutaka Uchiyama (JPN), 28 (Loss to Carreno Busta 4-6 6-3 1-6 6-3 6-3)
19. J.J. Wolf (USA), 18 (d. Pella 6-2 0-6 6-3 6-3)
20. Mikael Ymer (SWE), 21 (Loss to Krajinovic 6-2 7-6(3) 6-3)
Men’s Singles, Grand Slam Debuts (5 wins 5 losses)
1. Attila Balazs, HUNGARY, 31 (Loss to Kukushkin 6-4 7-5 6-4)
2. Ulises Blanch, USA, 22 (Loss to Garin 4-6 5-7 6-4 6-4 6-2)
3. Federico Coria, ARGENTINA, 28 (d. Jung 2-6 4-6 6-4 6-1 2-0 RET)
4. Maxime Cressy, USA, 23 (d. Kovalik 6-1 2-6 6-4 6-4)
5. Sebastian Korda, USA, 20 (Loss to Shapovalov 6-4 4-6 6-3 6-2)
6. Gianluca Mager, ITALY, 25 (Loss to Kecmanovic 6-4 6-4 6-7(6) 3-6 6-2)
7. Brandon Nakashima, USA, 19 (d. Lorenzi 6-3 6-2 7-6(3))
8. Emil Ruusuvuori, FINLAND, 21 (d. Bedene 6-3 3-6 6-1 4-6 6-1)
9. Thiago Seyboth Wild, BRAZIL, 20 (Loss to Evans 6-1 6-2 7-6(5)
10. JJ Wolf , USA, 18 (d. Pella 6-2 0-6 6-3 6-3)
Women’s Singles, Grand Slam Debuts (2 wins six losses)
1. Varvara Gracheva, RUSSIA, 20 (d. Paula Badosa, 6-4 7-5, R1)
2. Usua Mataine Arconada, USA, 21 (Loss to Juvan 6-4 7-6(2))
3. Hailey Baptiste, USA, 18 (Loss to Mladenovic 7-5, 6-2)
4. Katarzyna Kawa, POLAND, 27 (Loss to Jabeur 6-2 7-6(6))
5. Tamara Korpatsch, GERMANY, 25 (Loss to Bellis, 6-7(13), 6-3 6-2)
6. Robin Montgomery, USA, 15 (Loss to Putintseva 6-1 6-3)
7. Katrina Scott, USA, 16 (d. Vikhlyantseva 7-6(3) 6-2)
8. Katarina Zavatska, UKRAINE, 20 (Loss to Rybakina 6-3 6-0)
Men’s Singles, Players Searching for First Grand Slam Win (records entering US Open) (9 wins, 11 losses)
1. Marcos Giron (0-4), USA, 27 (d. Polmans 6-4 6-7(5) 3-6 6-4 6-2)
2. Josef Kovalik (0-8), SLOVAKIA, 27 (Loss to Cressy 6-1 2-6 6-4 6-4)
3. Mitchell Krueger (0-2), USA, 26 (d. Sousa 3-6 6-2 7-5 6-3)
4. Thai Son Kwiatkowski (0-1), USA, 25 (Loss to Kwon 3-6 7-6(4) 6-1 6-2)
5. Attila Balazs (0-0), HUNGARY, 31 (Loss to Kukushkin 6-4 7-5 6-4)
6. Ulises Blanch (0-0), USA, 22 (Loss to Garin 4-6 5-7 6-4 6-4 6-2)
7. Federico Coria (0-0), ARGENTINA, 28 (d. Jung 2-6 4-6 6-4 6-1 2-0 RET)
8. Maxime Cressy (0-0), USA, 23 (d. Kovalik 6-1 2-6 6-4 6-4)
9. Jason Jung (0-1), TAIWAN, 31 (Loss to Coria 2-6 4-6 6-4 6-1 2-0 RET)
10. Sebastian Korda (0-0), USA, 20 (Loss to Shapovalov 6-4 4-6 6-3 6-2)
11. Gianluca Mager (0-0), ITALY, 25 (Loss to Kecmanovic 6-4 6-4 6-7(6) 3-6 6-2)
12. Brandon Nakashima (0-0), USA, 19 (d. Lorenzi 6-3 6-2 7-6(3))
13. Christopher O’Connell (0-2), AUSTRALIA, 26 (d. Djere 4-6 6-4 7-6(2) 6-4)
14. Emil Ruusuvuori (0-0), FINLAND, 21 (d. Bedene 6-3 3-6 6-1 4-6 6-1)
15. Mohamed Safwat (0-2), EGYPT, 29 (Loss to Simon 6-1 6-4 6-4)
16. Thiago Seyboth Wild (0-0), BRAZIL, 20 (Loss to Evans 6-1 6-2 7-6(5))
17. Pedro Sousa (0-1), PORTUGAL, 32 (Loss to Krueger, 3-6 6-2 7-5 6-3)
18. Yasutaka Uchimaya (0-2), JAPAN, 28 (Loss to Carreno Busta 4-6 6-3 1-6 6-3 6-3)
19. JJ Wolf (0-0) , USA, 18 (d. Pella 6-2 0-6 6-3 6-3)
20. Norbert Gombos (0-1), SLOVAKIA, 30 (d. Albot 6-4 6-1 6-4)
21. Soonwoo Kwon (0-4), SOUTH KOREA, 22 (d. Kwiatkowski 3-6 7-6(4) 6-1 6-2)
22. Sumit Nagal (0-1) INDIA (d. Klahn 6-1 6-3 3-6 6-1)
Women’s Singles, Players Searching for First Grand Slam Win (records entering US Open) 4 wins, 16 losses
1. Ysaline Bonaventure (0-1), BELGIUM, 26 (d. Zhang 4-6 6-3 6-2)
2. Varvara Gracheva (0-0), RUSSIA, 20 (d. Paula Badosa, 6-4 7-5, R1)
3. Maddison Ingilis (0-1), AUSTRALIA, 22 (Loss to Linette, 6-4 4-6 6-4)
4. Irina Kromacheva (0-3), RUSSIA, 25 (Loss to Rogers 6-3 6-2)
5. Usua Mataine Arconada (0-0), USA, 21 (Loss to Juvan 6-4 7-6(2)
6. Hailey Baptiste (0-0), USA, 18 (Loss to Mladenovic 7-5, 6-2)
7. Katarzyna Kawa (0-0), POLAND, 27 (Loss to Jabeur 6-2 7-6(6))
8. Tamara Korpatsch (0-0), GERMANY, 25 (Loss to Bellis, 6-7(13), 6-3 6-2)
9. Robin Montgomery (0-0), USA, 15 (Loss to Putintseva 6-1 6-3)
10. Jasmine Paolini (0-2), ITALY, 24 (Loss to Garcia 6-3 6-2)
11. Liudmila Samsonova (0-2), RUSSIA, 21 (Loss to Pironkova 6-2 6-3)
12. Katrina Scott (0-0), USA, 16 (d. Vikhlyantseva 7-6(3) 6-2)
13. Nina Stojanovic (0-1), SERBIA, 24 (Loss to Kalinskaya 6-4 6-3)
14. Katarina Zavatska (0-0), UKRAINE, 20 (Loss to Rybakina 6-3 6-0)
15. Lizette Cabrera (0-1), AUSTRALIA, 22 (Loss to Kovinic 6-4 3-6 6-2)
16. Barbara Haas ((0-1), AUSTRIA, 24 (Loss to Azarenka 6-1 6-2)
17. Allie Kiick (0-1), USA, 25 (Loss to Bondarenko 3-6 6-3 6-1)
18. Tereza Martincova (0-1), CZECH REPUBLIC, 25 (Loss to Martic 5-7 6-2 6-4)
19. Whitney Osuigwe (0-2), USA, 18 (Loss to Kozlova 6-3 7-5)
20. Patricia Maria Tig (0-1), ROMANIA, 26 (d. Kurumi Nara 6-1 6-0)