Elena Vesnina partnered Ekaterina Makarova to win the US Open doubles title four years ago.
Vesnina won't be competing at Flushing Meadows this month.
More: Tsurenko Stuns Defending Champion Muguruza
The 2017 Indian Wells champion officially withdrew from the US Open today due to a recurring left knee injury.
Marketa Vondrousova, of the Czech Republic, moves into the main draw with Vesnina's departure.
Photo credit: Billie Weiss/BNP Paribas Open Facebook